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DOC News    October 1, 2004
Volume 1 Number 2 p. 22
© 2004 American Diabetes Association

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Impaired Glucose Tolerance Linked to CHD

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) may indicate greater risk of coronary heart disease (CHD) among prediabetic patients, according to a new report.

Researchers at the Diabetes Center and Department of Medicine at Massachusetts General Hospital and Harvard Medical School followed 937 nondiabetic subjects who also had no known coronary heart disease at the beginning of the study. Glucose tolerance categories were classified using American Diabetes Association diagnostic criteria or modified criteria redefining IFG as 100–126 mg/dl. The subjects were then tested every 6 months for 9.5 years. Patients who developed diabetes in follow-up were excluded from the analysis.

The study showed no connection between CHD and normal glucose tolerance or IFG. The researchers noted a distinct link with CHD risk factors and subjects with IGT alone or when combined with IFG.

Researchers concluded that patients with IGT should be more aggressively targeted with strategies to reduce CHD risk.

Blake DR, Meigs JB, Muller DC, Najjar SS, Andres R, Nathan DM: Impaired glucose tolerance, but not impaired fasting glucose, is associated with increased levels of coronary heart disease risk factors. Diabetes 53:2095–2100, 2004.[Abstract/Free Full Text]


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