DOC News October 1, 2004
Volume 1 Number 2 p. 22
© 2004 American Diabetes Association
Impaired Glucose Tolerance Linked to CHD
Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) may
indicate greater risk of coronary heart disease (CHD) among prediabetic
patients, according to a new report.
Researchers at the Diabetes Center and Department of Medicine at
Massachusetts General Hospital and Harvard Medical School followed 937
nondiabetic subjects who also had no known coronary heart disease at the
beginning of the study. Glucose tolerance categories were classified using
American Diabetes Association diagnostic criteria or modified criteria
redefining IFG as 100126 mg/dl. The subjects were then tested every 6
months for 9.5 years. Patients who developed diabetes in follow-up were
excluded from the analysis.
The study showed no connection between CHD and normal glucose tolerance or
IFG. The researchers noted a distinct link with CHD risk factors and subjects
with IGT alone or when combined with IFG.
Researchers concluded that patients with IGT should be more aggressively
targeted with strategies to reduce CHD risk.
Blake DR, Meigs JB, Muller DC, Najjar SS, Andres R, Nathan
DM: Impaired glucose tolerance, but not impaired fasting glucose, is
associated with increased levels of coronary heart disease risk factors.
Diabetes 53:20952100, 2004.[Abstract/Free Full Text]

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