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Metabolic Syndrome and Mortality

Researchers at Bristol-Myers Squibb and the University of California collaborated to examine the impact of metabolic syndrome on CHD, CVD, and overall mortality among U.S. adults. More than 6,200 subjects, 30 to 75 years of age, were followed for an average of 13.3 years.

Patients with diabetes and CVD are at the highest risk of mortality. Those with even one or two metabolic syndrome risk factors were twice as likely to die from CHD and CVD. Metabolic syndrome more strongly predicts CHD, CVD, and total mortality than its individual components. Results of the study revealed that mortality risk from CHD and CVD is elevated in persons with metabolic syndrome even without the presence of diabetes.

Malik S, Wong ND, Franklin SS, et al.: Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 110:1245–1250, 2004.[Abstract/Free Full Text]

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