DOC News January 1, 2005
Volume 2 Number 1 p. 22
© 2005 American Diabetes Association
CVD Risk Factors Predict Type 2 Diabetes
A number of studies show the presence of increased cardiovascular risk
factors before the onset of diabetes. It's possible that high cholesterol and
high blood pressure, in addition to obesity and cigarette smoking, may lead to
not only increased cardiovascular disease (CVD), but also increased risk for
type 2 diabetes.
Researchers in the U.S. and Finland collaborated to determine whether CVD
risk factors predicted development of diabetes after controlling for insulin
resistance, obesity, and other variables. Researchers studied 872 participants
with normal or impaired glucose tolerance who were enrolled in the Insulin
Resistance Atherosclerosis Study. One hundred forty-three subjects (16%)
developed diabetes in 5 years.
Results of the study showed that significant risk factors for developing
type 2 diabetes included high plasminogen activator inhibitor-1, high blood
pressure, high triglycerides, low levels of HDL cholesterol, and impaired
glucose tolerance. Each additional risk factor more than doubled the risk of
type 2 diabetes.
Agostino RB, Hamman RF, Karter AJ, Mykkanen L, Wagenknecht
LE, Haffner SM: Cardiovascular disease risk factors predict the development of
type 2 diabetes. Diabetes Care 27: 2234–2240, 2004.[Abstract/Free Full Text]
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
