DOC News October 1, 2005
Volume 2 Number 10 p. 12
© 2005 American Diabetes Association
Cardiac Perfusion Impaired by High Postprandial Blood Glucose
High postprandial glucose levels have a significant negative effect on
cardiac perfusion in people with type 2 diabetes, according to a clinical
study conducted by researchers at University of Padova Medical School in
Italy.
Postprandial glucose levels are a risk factor for cardiovascular disease,
and hyperglycemia has been shown to affect endothelial function. But little is
known about the influence of postprandial hyperglycemia on cardiac
perfusion.
Roldano Scognamiglio, MD, and colleagues tested the effects of a
standardized mixed meal on 20 healthy volunteers and 20 consecutive patients
with type 2 diabetes who did not have any vascular disease. Myocardial
perfusion was assessed by contrast echocardiography.
While normal subjects experienced an increase of myocardial blood flow and
volume after a meal, measures of perfusion diminished in participants with
type 2 diabetes.
Although featuring a modest sample, the study suggests that postprandial
hyperglycemia may be an early warning sign of cardiovascular disease.
"From a clinical point of view, controlling postprandial hyperglycemia
and myocardial perfusion defects may constitute important goals in the
treatment of the disease," the group concludes.
Scognamiglio R, Negut C, De Kreutzenberg SV, et al.:
Postprandial myocardial perfusion in healthy subjects and in type 2 diabetic
patients. Circulation 112:179–184, 2005.[Abstract/Free Full Text]
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