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Abdominal Obesity Predicts Insulin Sensitivity

The finding was a result of an analysis of the Insulin ResistanceAtherosclerosis Study (IRAS), which is looking at the links between insulinand insulin resistance and atherosclerosis and its risk factors in diabeticand nondiabetic men and women.

The analysis included 504 people without diabetes 40–60 years of age,who were enrolled in Oakland and Los Angeles, Calif., San Antonio, Texas, andSan Luis Valley, Colo.

Each participant's evaluation included lab tests to assess insulin andglucose balance during the 1992–1994 baseline period, then again 5 yearslater.

When sex, ethnicity, physical activity, and other factors were controlled,investigators found that waist size, but not body mass index (BMI), was a"strong predictor" of declining insulin sensitivity. Measuring thewaist is quick, easy, and inexpensive, the group points out. Waistcircumference should be considered along with BMI when identifying people athigh risk of diabetes or insulinresistance.

Karter AJ, D'Agostino RB, Mayer-Davis EJ, et al.: Abdominalobesity predicts declining insulin sensitivity in non-obese normoglycaemics:The Insulin Resistance Atherosclerosis Study (IRAS). Diabetes ObesMetab 7:230–238, 2005.[Medline]

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