DOC News November 1, 2005
Volume 2 Number 11 p. 12
© 2005 American Diabetes Association
Dermolipectomy Improves Insulin Action and Inflammation
Some people struggling with overweight or obesity turn to dermolipectomy
("tummy tuck") to reduce body fat and remove excess folds of
flesh. A new study suggests that dermolipectomy can improve insulin action in
the body and can lower markers of inflammation.
Investigators at University of Naples studied the effect of dermolipectomy
on 20 women. The participants were 25–40 years of age, nonsmokers,
without diabetes or disease of the heart and blood vessels. All of the women
ate a standard diet during the study. Patients were measured for body weight
and composition before surgery and 40 days afterward. They also had blood
tests to measure insulin and glucose activity and signs of inflammation. An
average of 2.3 kg (5.07 lb) of flesh was removed in surgery.
Blood tests done after surgery showed a healthful improvement in the body's
ability to handle insulin and glucose. After dermolipectomy, the women were
found to have improved markers of inflammation, including lower interleukin-6
(IL-6), tumor necrosis factor, and soluble IL-6 receptors. They had lower
plasma resistin and higher levels of plasma
adiponectin.
Although dermolipectomy improves insulin function and inflammation, further
research is needed to determine whether the surgery reduces the risk of
cardiovascular disease.
Rizzo MR, Paolisso G, Grella R, et al.: Is dermolipectomy
effective in improving insulin action and lowering inflammatory markers in
obese women? Clin Endocrinol 63: 253–258, 2005[Medline].
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