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Effects of Polycystic Ovary Syndrome

A group of investigators at Medical College of Virginia did a retrospectivereview of all women treated for PCOS at their endocrinology clinic during a3-year period. In all, 106 women were studied. The women were divided into twogroups: those with metabolic syndrome (46 women) and those without metabolicsyndrome (60 women). Metabolic syndrome is a cluster of symptoms includinginsulin resistance, hypertension, high HDL cholesterol and triglycerides, andlarge waist size.

Among the whole study population of women with PCOS, the prevalence ofmetabolic syndrome was 43%, nearly twice the rate reported for age-matchedwomen in the general population. Among women 20–29 years of age, theprevalence of metabolic syndrome was eightfold that of similar women in thegeneral population, and among women 30–39 years, the prevalence ofmetabolic syndrome was fourfold that of similarwomen.

Women with PCOS and metabolic syndrome had higher levels of serum-freetestosterone and lower levels of sex hormone–binding globulin. Theauthors conclude that metabolic syndrome is common among women with PCOS, andthey are therefore at greater risk of cardiovascular disease.

Apridonidze T, Essah PA, Iuorno MJ, et al.: Prevalence andcharacteristics of the metabolic syndrome in women with polycystic ovarysyndrome. J Clin Endocrinol Metab 90: 1929–1935, 2005.[Abstract/Free Full Text]

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