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Type 2 Diabetes in Youth Linked to Renal Disease

A group of researchers conducted a long-term study of the incidence of diabetes-related end-stage renal disease and mortality in Pima Indians of Arizona. From 1965 until 2002, they followed 1,856 participants with diabetes, 96 of whom developed the disease during youth.

Those who had an onset of type 2 diabetes were 4.6 times more likely to develop end-stage renal disease in middle age and three times more likely to die in middle age than people who developed diabetes as an adult. The long duration of diabetes clearly has an effect on the body, and efforts should focus on preventing diabetes and renal disease, the researchers conclude.

Pavkov ME, Bennett PH, Knowler WC, et al.: Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA 296:421–426, 2006[Abstract/Free Full Text] .

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