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Low Birth Weight Linked to Fetal A1C

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Investigators measured A1C levels in 1,295 consecutive babies born at a medical center in Berlin, Germany, and in their mothers. Analysis considered factors including gestational age at delivery, the child's sex, maternal body mass index, and smoking during pregnancy. An inverse relationship was found between total fetal and maternal A1C and birth weight. Each 1% increase in fetal A1C was associated with an average birth weight reduction of 135 g (0.3 lb), while the same increase in the mother's A1C was linked to an average birth weight increase of 88 g (0.2 lb).

"The ratio of fetal/maternal [A1C] suggests that lighter newborns have a higher percentage of [A1C] than would be expected from maternal [A1C]," researchers conclude. "The study demonstrates for the first time in a large population that there is an inverse association between [A1C] of a newborn and its birth weight."

Pfab T, Slowinski T, Godes M, et al.: Low birth weight, a risk factor for cardiovascular diseases in later life, is already associated with elevated fetal glycosylated hemoglobin at birth. Circulation 114:1687–1692, 2006 .

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Services Email this article to a friend Similar articles in this journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                What's this?