DOC News December 1, 2006
Volume 3 Number 12 p. 11
© 2006 American Diabetes Association
Dissecting Diabetes Risk Reduction
The Diabetes Prevention Program (DPP) showed that a program of intensive
lifestyle intervention can reduce the incidence of diabetes by nearly 60%
compared with placebo. The lifestyle intervention included prescribed dietary
changes and physical activity. But what contributed most to the reduction of
diabetes risk—weight loss, dietary changes, or increased physical
activity? To further discern the relative contribution of each component of
the intervention, researchers did a further analysis of DPP data.
DPP included 1,079 participants 25–84 years of age, with an overall
average body mass index of 33.4. Participants had a physical exam and blood
tests to assess glycemic control. The intensive lifestyle intervention
included goals to reduce weight by 7% from baseline, maintain at least 150
minutes of moderate physical activity per week, and reduce total dietary fat
to <25% of calories. Participants met with a lifestyle counselor weekly for
16 sessions and at least twice a month after that.
Analysis of data revealed that weight loss was the strongest predictor of
reduced diabetes risk. Every kilogram of weight loss was associated with a 16%
reduction in risk. A diet lower in fat and increased physical activity
predicted those who lost weight. "Interventions to reduce the incidence
of diabetes should primarily target weight loss," the researchers
conclude.
Hamman RF, Wing RR, Edelstein SL, et al.: Effect of weight
loss with lifestyle intervention on risk of diabetes. Diabetes
Care 29:2102–2107, 2006[Abstract/Free Full Text]
.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
