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Endothelial Dysfunction Precedes Diabetes

A group of investigators studied 2,924 participants of the Framingham Offspring Study, who are spouses and children of the original Framingham Heart Study subjects. The offspring were an average age of 54 years, and none of them had diabetes. Participants had blood drawn for markers of endothelial dysfunction, including plasminogen activator inhibitor-1 antigen, von Willebrand factor antigen, and C-reactive protein.

During the 7-year follow-up period, there were 153 new cases of type 2 diabetes among the offspring. Researchers observed an increase in markers of endothelial dysfunction that strongly correlated with diabetes. The relationship remained strong when other factors were controlled for, including obesity, insulin resistance, and inflammation.

Although testing for markers of endothelial dysfunction may not be practical or useful in the clinical setting, the research suggests that therapies aimed at improving endothelial dysfunction may reduce the risk of diabetes.

Meigs JB, O'Donnell CJ, Tofler GH, et al.: Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: The Framingham Offspring Study. Diabetes 55: 530–537, 2006[Abstract/Free Full Text] .

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This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                What's this?