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Better Mental Functioning Through Glycemic Control

A group of investigators studied intensive glycemic therapy in 145 older adults with type 2 diabetes. Participants took metformin with an add-on of rosiglitazone or glyburide. Cognitive functioning was tested at baseline and after 24 weeks of therapy.

After treatment, both groups showed significant improvements in fasting plasma glucose levels—and also working memory function. One cognitive scale showed 25–31% reduction in errors that correlated very highly with improved glycemic control. The underlying mechanism is not well understood, and it isn't known whether the effects are long-lasting or also are seen in more severe forms of mental impairment.

Ryan CM, Freed MI, Rood JA, et al.: Improving metabolic control leads to better working memory in adults with type 2 diabetes. Diabetes Care 29:345–351, 2006[Abstract/Free Full Text] .

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This Article Full Text (PDF) Services Email this article to a friend Similar articles in this journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                What's this?