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DOC News    May 1, 2006
Volume 3 Number 5 p. 12
© 2006 American Diabetes Association

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Preventing Heart Attacks

Insulin-sensitizing therapy can reduce the risk of heart attack among people with type 2 diabetes by one-third to one-half, according to a study recently published in American Journal of Cardiology.

Researchers studied all people with type 2 diabetes hospitalized for a first heart attack within a five-county area around Philadelphia during a 56-month period. For comparison purposes, a randomly selected group of people with diabetes in the community was evaluated as well. Patients who were on monotherapy with thiazolidinedione had one-third the risk, and those on monotherapy with metformin were nearly half as likely to suffer a heart attack as those on sulfonylurea alone. Adding thiazolidinedione to sulfonylurea significantly reduced heart attack risk, while metformin did not.

Further research may help shed light on potential differences in insulin-sensitizing drugs, the authors conclude.

Sauer WH, Cappola AR, Berlin JA, et al.: Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus. Am J Cardiol 87: 651–654, 2006 .


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