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DOC News asked:
Are drugs safer now than in years past?
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In the areas of insulin, they are a lot safer, like analogs [have] more predictable peaks. In terms of all agents, it may not be easy to compare the last 10 years to the previous 10 years because we are so aware of adverse events now. There is more scrutiny. In general, drugs are safer.
Ramim Alemzadeh, MD
Pediatrics
Milwaukee, Wis.
They are the same. People want more drugs, they take more, and we see more side effects. All drugs have issues, and as prescribers we have to be aware of them.
Stephanie Hsu, MD
Endocrinology
Baltimore, Md.
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Some of the new COX-2 inhibitors—it makes you think. They're brand-new, and we haven't discovered the complications yet. I'm a little slow starting my patients on new drugs. I'm a little cautious.
Jim Harjo, DO
Primary Care
Creek Nation Community Hospital
Okemah, Okla.
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Drugs are safer because there is more scrutiny and rapid dissemination of information. A good example is the latest alpha/gamma-PPAR [peroxisome proliferator–activated receptor]. All the information submitted to the FDA was available on the Web site. That's how people were able to access and analyze the data before the FDA made a final decision. That sort of thing was not available a few years ago.
Michael Bryer-Ash, MD
Director, Diabetes Center
University of California, Los Angeles
TALK BACK: UNDER THE INFLUENCE
The American Medical Association, the Pharmaceutical Research and Manufacturers of America, and other groups have adopted guidelines to limit the influence of drug companies in the clinical setting. Yet a study of 107 general practitioners in Great Britain shows that doctors are more likely to rely on information from drug companies than from other independent sources, even though the information may be misleading, biased, or inaccurate.1 Another study suggests that doctors who participate in clinical trials are more likely to prescribe the sponsors' drugs.2
What do you think? Do drug companies have too much influence over the prescribing patterns of physicians?
Send your comments to docnews{at}diabetes.org.
References
2. Andersen M, Kragstrup J, Sondergaard J: How conducting a clinical
trial affects physicians' guideline adherence and drug preferences.
JAMA 295:2759–2764, 2006.
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