DOC News September 1, 2006
Volume 3 Number 9 p. 13
© 2006 American Diabetes Association
Exercise and Acarbose Improve Metabolic Control
Not only is diabetes a risk factor for cardiovascular disease, but evidence
is growing that impaired fasting glucose is a risk as well. New research
suggests that a combination of exercise training and acarbose (Precose, Bayer)
can improve insulin sensitivity and may also reduce cardiovascular risk
factors in people with mild type 2 diabetes.
Henrik Wagner, MD, and colleagues at Karolinska Institute in Stockholm,
Sweden, studied the effect of acarbose and exercise training on glycemic
control and insulin sensitivity in 62 men and women with type 2 diabetes.
Participants were randomized to 12 weeks of structured exercise training with
or without acarbose.
Exercise alone improved insulin sensitivity, decreased body fat, and
reduced systolic blood pressure, but had no effect on oxygen uptake or
glycated hemoglobin (A1C). Acarbose alone had no effect on insulin sensitivity
or A1C levels, but lowered systolic and diastolic blood pressure as well as
fasting proinsulin levels.
The combination of exercise and acarbose decreased fasting plasma glucose,
A1C, lipids, diastolic blood pressure, and oxygen uptake. This combination is
"associated with significant improvement in glycemic control and
possibly cardiovascular risk factors," researchers conclude.
Wagner H, Degerblad M, Thorell A, et al.: Combined
treatment with exercise training and acarbose improves metabolic control and
cardiovascular risk factor profile in subjects with mild type 2 diabetes.
Diabetes Care 29:1471–1477, 2006[Abstract/Free Full Text]
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