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Statin Therapy Safe, Effective in Elderly With Diabetes

While previous studies showed that statin therapy is safe and effective in younger adults, members of the Collaborative Atorvastatin Diabetes Study (CARDS) group decided to conduct a post hoc analysis to see if that holds true for patients 65–75 years at the beginning of the study.

CARDS was a randomized, placebo-controlled trial of 10 mg/day atorvastatin for the primary prevention of cardiovascular disease in people with diabetes. The study included 1,129 people aged 65–75 years at the time of randomization. Participants were followed for an average of 3.9 years.

Analysis revealed that atorvastatin therapy reduced the risk of first major cardiovascular events by 38% in older adults, about the same effect observed in younger adults. There also was a reduction in all-cause mortality, which the researchers said did not reach statistical significance. The safety profile of atorvastatin was similar in older adults and younger adults, according to researchers.

Neil HA, DeMicco DA, Luo D, et al.: Analysis of efficacy and safety in patients aged 65–75 years at randomization: Collaborative Atorvastatin Diabetes Study (CARDS). Diabetes Care 29: 2378–2384, 2006.[Abstract/Free Full Text]

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