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DOC News    December 1, 2007
Volume 4 Number 12 p. 11
© 2007 American Diabetes Association

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Lower Extremity Disease Provides Diabetes Diagnosis Tip-off

The prevalence of lower extremity diseases (LEDs) such as peripheral neuropathy and peripheral arterial disease is nearly as high among people with undiagnosed diabetes as among those with diagnosed cases, research indicates. However, people with impaired fasting glucose—a marker of pre-diabetes—had LED rates as low as those with normal glucose levels.


Figure 1
MEDIO IMAGES/JUPITER IMAGES

A group of investigators from the Centers for Disease Control and Prevention analyzed data on 3,607 people ages ≥40 who participated in the National Health and Nutrition Examination Survey (NHANES). Each participant underwent testing to detect LEDs.

LEDs occurred most often in people with diabetes and least frequently in people with normal blood glucose levels or impaired fasting glucose (pre-diabetes). People with undiagnosed diabetes were about as likely to have an LED as those diagnosed with the disease.

Researchers conclude that LEDs are common in people with diabetes, including those with undiagnosed diabetes, but that rates are similarly low in people with impaired fasting glucose or normal glucose levels. Results suggest people with undiagnosed diabetes are a target population for LED detection, they add.

Gregg EW, Gu Q, Williams D, et al.: Prevalence of lower extremity diseases associated with normal glucose levels, impaired fasting glucose, and diabetes among U.S. adults aged 40 or older. Diab Res Clin Pract 77:485–488, 2007.[Medline]


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