DOC News December 1, 2007
Volume 4 Number 12 p. 7
© 2007 American Diabetes Association
Two-hour Glucose Levels Predict Hypertension
Bruce Goldfarb
New evidence suggests that postprandial glucose levels may be key to
cardiovascular risk. High 2-hour plasma glucose (2hPG) levels appear to raise
the risk of developing hypertension within 5 years, according to an analysis
of data from the Australian Diabetes, Obesity, and Lifestyle Study
(AusDiab).
People with an average 2hPG of 115 mg/dl were about 36% more likely to
develop hypertension within 5 years than those with an average 2hPG of 103
mg/dl, according to results presented at the European Association for the
Study of Diabetes annual meeting, held September 18–21 in Amsterdam.
AusDiab involved 4,306 participants, with an average age of 47, who had a
detailed medical exam and blood tests to measure glycemia and insulin levels.
Over 5 years, 14% of the participants developed hypertension, defined as a
pressure of 
140 mmHg for systolic and 90 mmHg for diastolic.
Analysis of data showed a smooth linear relationship between 2hPG and
hypertension over the 5-year period, with higher blood pressure associated
with higher 2hPG even in the normal 2hPG range.
Interventions aimed at reducing the 2hPG level may "potentially yield
additional benefits through reduction in hypertension," according to
Elizabeth Barr, MPH, an epidemiologist at the International Diabetes Institute
in Melbourne, Australia. 
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