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Diabetes Drugs Don't Boost Beta-Cell Function

Investigators evaluated beta-cell function and insulin sensitivity in 50 volunteer participants with impaired glucose tolerance or a history of gestational diabetes. After 10 weeks of maximal treatment with metformin or pioglitazone, tests were repeated to assess beta-cell function.

Although improved beta-cell compensation was noted among participants with the lowest insulin sensitivity, "we did not find any evidence that either pioglitazone or metformin improved beta-cell function," researchers conclude.

Rasouli N, Kern PA, Reece EA, et al.: Effects of pioglitazone and metformin on beta-cell function in nondiabetic subjects at high risk for type 2 diabetes. Am J Physiol Endocrinol Metab 292:e359–e365, 2007 .

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Services Email this article to a friend Similar articles in this journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                What's this?