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Glimepiride Similar to Metformin in Pediatric Type 2 Patients

Researchers compared the drugs in a 26-week single-blind trial with 285 subjects. Participants were randomized to receive 1–8 mg of glimepiride daily or 500–1,000 mg of metformin twice daily for 24 weeks.

At the end of the study period, levels of glycated hemoglobin (A1C) were significantly lower in both groups. No differences in self-monitored blood glucose levels, serum lipids, or incidence of hypoglyce mia were observed. However, participants taking glimepiride gained an average 1.97 kg (4.34 lb), while those on metformin gained 0.55 kg (1.21 lb).

"Glimepiride reduced A1C similarly to metformin with greater weight gain, and there was comparable safety over 24 weeks in the treatment of pediatric subjects with type 2 diabetes," the researchers conclude.

Gottschalk M, Danne T, Vlajnic A, et al.: Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes. Diabetes Care 30:790–794, 2007.[Abstract/Free Full Text]

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