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Metabolic Syndrome Predicts New-Onset Diabetes

The presence of metabolic syndrome strongly predicts new-onset diabetes, independent of its components and other variables, according to research presented at the annual meeting of the American Society of Hypertension, held May 19–22 in Chicago.

Metabolic syndrome is a clustering of risk factors linked to cardiovascular disease and diabetes that includes a large waist size, hypertension, impaired glucose metabolism, and dyslipidemia.

Ajay K. Gupta, MD, of the International Center for Circulatory Health in London, and colleagues analyzed data from the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA) study to determine whether metabolic syndrome was linked to new-onset diabetes.

The study included 19,527 people with hypertension, 40–79 years old, who had three or more cardiovascular risk factors but no history of previous or active coronary heart disease or stroke. Those with diabetes were excluded from the study. The researchers followed the subjects for 5 years.

Nearly 32% of the participants were found to have metabolic syndrome. Of these, 17.7% developed diabetes during the study period, compared with 5.9% who did not have metabolic syndrome at baseline—indicating a nearly threefold risk among participants with metabolic syndrome.

The risk of developing diabetes increased steadily with the increase in the number of components of metabolic syndrome noted at baseline, according to Gupta.

Statistical analysis revealed the link between metabolic syndrome and development of diabetes remained strong even after controlling for other factors. One statistical model that controlled for ethnicity, age, and sex, still found a threefold increase in risk among participants with metabolic syndrome.

The relationship was attenuated but remained significant when the researchers factored in fasting plasma glucose, body mass index, HDL cholesterol, triglycerides, and systolic blood pressure. When the researchers added other independent factors to the model, including alcohol intake and total cholesterol, a 23% excess risk of new-onset diabetes remained among people with metabolic syndrome.

"The use of metabolic syndrome as a predictor of new-onset diabetes among hypertension patients should be encouraged in the clinical setting," says Gupta.

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Services Email this article to a friend Similar articles in this journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Goldfarb, B. Search for Related Content PubMed Articles by Goldfarb, B. Social Bookmarking                What's this?